Prehospital Rapid Sequence Intubation Improves Functional Outcome for Patients with Severe Traumatic Brain Injury: Bernard S, Nguyen V, Cameron P, et al. Ann Surg 2010;252:959–65.

This multicenter study from Victoria, Australia was a prospective, randomized, controlled trial comparing long-term neurologic outcomes in patients with severe traumatic brain injury (TBI) who receive paramedic Rapid Sequence Intubation (RSI) vs. hospital intubation. The primary outcome measure was the median extended Glasgow Outcome Scale (GOSe) score at 6 months. Secondary end points were favorable vs. unfavorable outcome at 6 months, length of intensive care and hospital stay, and survival to hospital discharge. Patients were included in the study if there was evidence of head trauma, Glasgow Coma Score15 years, and intact airway reflexes. Patients were excluded if they were within 10min of a designated trauma hospital, had no intravenous access, had an allergy to any of the RSI drugs, …

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