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A case of frontal neuropsychological and neuroimaging signs following multiple primary-blast exposure.

Posted on August 31st 2011
This study supports the existence of primary blast-induced neurotrauma in humans and introduces a neuroimaging technique with potential to discriminate multiple-blast TBI. We would like to thank J.G. for sharing his story with us, Elizabeth Selgrade and Gregory McCarthy for helpful discussions regarding the project, and Christopher Lascola for providing a neuroradiology consult. We would also like to acknowledge the contributions of the Mid-Atlantic Mental Illness Research, Education, and Clinical Center workgroup (members include Jean C. Beckham, Patrick S. Calhoun, Rita M. Davison, A. Meade Eggleston, John A. Fairbank, Kimberly T. Green, Angela C. Kirby, Harold Kudler, Jeffrey M. Hoerle, Christine E. Marx, Scott D. Moore, Victoria Payne, Mary C. Pender, Jennifer L. Strauss, Kristy K. Str...

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Brain Iron Quantification in Mild Traumatic Brain Injury: A Magnetic Field Correlation Study [BRAIN]

Posted on August 31st 2011
CONCLUSIONS: MFC values were significantly elevated in the thalamus and globus pallidus of patients with mTBI, suggesting increased accumulation of iron. This supports the hypothesis that deep gray matter is a site of injury in mTBI and suggests a possible role for iron accumulation in the pathophysiological events after mTBI. (Source: American Journal of Neuroradiology)


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Cytoreductive treatment with Clofarabine / Ara‐C combined with reduced‐intensity conditioning and allogeneic stem cell transplantation in patients with high‐risk, relapsed, or refractory acute myeloid leukemia and advanced myelodysplastic syndrome

Posted on August 31st 2011
AbstractThe combination of cytoreductive chemotherapy with reduced intensity conditioning (RIC) is a highly‐effective anti‐leukemic therapy. Purpose of this retrospective analysis was to evaluate the anti‐leukemic efficacy and toxicity of clofarabine‐based chemotherapy followed by RIC and allogeneic stem cell transplantation (SCT) for high‐risk, relapsed or refractory acute myeloid leukemia or myelodysplastic syndromes (MDS). From May 2007 until October 2009 a total of 27 patients underwent allogeneic SCT after treatment with clofarabine and ara‐C for five days and RIC (4 Gy TBI/cyclophosphamide/ATG). Prophylaxis of graft versus host‐disease (GvHD) consisted of cyclosporine and mycophenolate mofetil. Unmanipulated G‐CSF mobilized PBSC (n = 26) or bone marrow cells (n = 1) w...


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Brain Iron Quantification in Mild Traumatic Brain Injury: A Magnetic Field Correlation Study [BRAIN]

Posted on August 31st 2011
CONCLUSIONS: MFC values were significantly elevated in the thalamus and globus pallidus of patients with mTBI, suggesting increased accumulation of iron. This supports the hypothesis that deep gray matter is a site of injury in mTBI and suggests a possible role for iron accumulation in the pathophysiological events after mTBI. (Source: American Journal of Neuroradiology)


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Cytoreductive treatment with Clofarabine / Ara‐C combined with reduced‐intensity conditioning and allogeneic stem cell transplantation in patients with high‐risk, relapsed, or refractory acute myeloid leukemia and advanced myelodysplastic syndrome

Posted on August 31st 2011
AbstractThe combination of cytoreductive chemotherapy with reduced intensity conditioning (RIC) is a highly‐effective anti‐leukemic therapy. Purpose of this retrospective analysis was to evaluate the anti‐leukemic efficacy and toxicity of clofarabine‐based chemotherapy followed by RIC and allogeneic stem cell transplantation (SCT) for high‐risk, relapsed or refractory acute myeloid leukemia or myelodysplastic syndromes (MDS). From May 2007 until October 2009 a total of 27 patients underwent allogeneic SCT after treatment with clofarabine and ara‐C for five days and RIC (4 Gy TBI/cyclophosphamide/ATG). Prophylaxis of graft versus host‐disease (GvHD) consisted of cyclosporine and mycophenolate mofetil. Unmanipulated G‐CSF mobilized PBSC (n = 26) or bone marrow cells (n = 1) w...

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