Posted on August 31st 2011
AbstractThe combination of cytoreductive chemotherapy with reduced intensity conditioning (RIC) is a highlyâeffective antiâleukemic therapy. Purpose of this retrospective analysis was to evaluate the antiâleukemic efficacy and toxicity of clofarabineâbased chemotherapy followed by RIC and allogeneic stem cell transplantation (SCT) for highârisk, relapsed or refractory acute myeloid leukemia or myelodysplastic syndromes (MDS). From May 2007 until October 2009 a total of 27 patients underwent allogeneic SCT after treatment with clofarabine and araâC for five days and RIC (4 Gy TBI/cyclophosphamide/ATG). Prophylaxis of graft versus hostâdisease (GvHD) consisted of cyclosporine and mycophenolate mofetil. Unmanipulated GâCSF mobilized PBSC (n = 26) or bone marrow cells (n = 1) w...
Posted on August 31st 2011
This study supports the existence of primary blast-induced neurotrauma in humans and introduces a neuroimaging technique with potential to discriminate multiple-blast TBI. We would like to thank J.G. for sharing his story with us, Elizabeth Selgrade and Gregory McCarthy for helpful discussions regarding the project, and Christopher Lascola for providing a neuroradiology consult. We would also like to acknowledge the contributions of the Mid-Atlantic Mental Illness Research, Education, and Clinical Center workgroup (members include Jean C. Beckham, Patrick S. Calhoun, Rita M. Davison, A. Meade Eggleston, John A. Fairbank, Kimberly T. Green, Angela C. Kirby, Harold Kudler, Jeffrey M. Hoerle, Christine E. Marx, Scott D. Moore, Victoria Payne, Mary C. Pender, Jennifer L. Strauss, Kristy K. Str...
Posted on August 31st 2011
AbstractThe combination of cytoreductive chemotherapy with reduced intensity conditioning (RIC) is a highlyâeffective antiâleukemic therapy. Purpose of this retrospective analysis was to evaluate the antiâleukemic efficacy and toxicity of clofarabineâbased chemotherapy followed by RIC and allogeneic stem cell transplantation (SCT) for highârisk, relapsed or refractory acute myeloid leukemia or myelodysplastic syndromes (MDS). From May 2007 until October 2009 a total of 27 patients underwent allogeneic SCT after treatment with clofarabine and araâC for five days and RIC (4 Gy TBI/cyclophosphamide/ATG). Prophylaxis of graft versus hostâdisease (GvHD) consisted of cyclosporine and mycophenolate mofetil. Unmanipulated GâCSF mobilized PBSC (n = 26) or bone marrow cells (n = 1) w...
Posted on August 31st 2011
This study supports the existence of primary blast-induced neurotrauma in humans and introduces a neuroimaging technique with potential to discriminate multiple-blast TBI. We would like to thank J.G. for sharing his story with us, Elizabeth Selgrade and Gregory McCarthy for helpful discussions regarding the project, and Christopher Lascola for providing a neuroradiology consult. We would also like to acknowledge the contributions of the Mid-Atlantic Mental Illness Research, Education, and Clinical Center workgroup (members include Jean C. Beckham, Patrick S. Calhoun, Rita M. Davison, A. Meade Eggleston, John A. Fairbank, Kimberly T. Green, Angela C. Kirby, Harold Kudler, Jeffrey M. Hoerle, Christine E. Marx, Scott D. Moore, Victoria Payne, Mary C. Pender, Jennifer L. Strauss, Kristy K. Str...
Posted on August 31st 2011
AbstractThe combination of cytoreductive chemotherapy with reduced intensity conditioning (RIC) is a highlyâeffective antiâleukemic therapy. Purpose of this retrospective analysis was to evaluate the antiâleukemic efficacy and toxicity of clofarabineâbased chemotherapy followed by RIC and allogeneic stem cell transplantation (SCT) for highârisk, relapsed or refractory acute myeloid leukemia or myelodysplastic syndromes (MDS). From May 2007 until October 2009 a total of 27 patients underwent allogeneic SCT after treatment with clofarabine and araâC for five days and RIC (4 Gy TBI/cyclophosphamide/ATG). Prophylaxis of graft versus hostâdisease (GvHD) consisted of cyclosporine and mycophenolate mofetil. Unmanipulated GâCSF mobilized PBSC (n = 26) or bone marrow cells (n = 1) w...
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