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Two-Year Outcome Following Traumatic Brain Injury and Rehabilitation: A Comparison of Patients From Metropolitan Melbourne and Those Residing in Regional Victoria

Conclusions: These findings suggest that outcomes in patients from regional areas are at least as good as those from metropolitan Melbourne. (Source: Brain Impairment)

Safety and efficacy of patient specific intramuscular injection of HGF plasmid gene therapy on limb perfusion and wound healing in patients with ischemic lower extremity ulceration: Results of the HGF-0205 trial

Conclusion: HGF gene therapy using a patient vascular anatomy specific delivery technique appears safe, maintained limb perfusion, and decreased rest pain in patients with CLI compared with placebo. A larger study to assess the efficacy of this therapy on more clinically relevant end points is warranted. (Source: Journal of Vascular Surgery)

Neuropharmacology in Pediatric Brain Injury: A Review

In this review, the current evidence is examined regarding neuropharmacologic treatment for children and adolescents (under the age of 18 years) who sustained a traumatic brain injury (TBI). Although the focus is on the pediatric TBI population, there is a paucity of empirical data related to the role of medication with children and adolescents after brain injury. Therefore, findings from the adult TBI literature are incorporated where appropriate so as to identify potential agents that warrant further examination in pediatric populations. This review addresses specific sequelae of TBI from the earliest stages of neurologic recovery to long-term comorbidities, including disorders of impaired consciousness, post-TBI agitation, cognitive decline, and post-TBI depression. The evidence regardi...

Spironolactone in preventing hypokalemia following traumatic brain injury.

Conclusion: Spironolactone within the first week of head injury could prevent the occurrence of late hypokalemia with no severe side effects. PMID: 21126390 [PubMed - in process] (Source: Chinese Journal of Traumatology)

Youth Motorcycle-Related Brain Injury by State Helmet Law Type: United States, 2005-2007

CONCLUSIONS: States with youth-specific laws had an increased risk of TBI that required hospitalization, serious and severe TBI, TBI-related disability, and in-hospital death among the youth they are supposed to protect. The only method known to keep motorcycle-helmet use high among youth is to adopt or maintain universal helmet laws. (Source: PEDIATRICS)
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