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Statistical analysis of dose heterogeneity in circulating blood: implications for sequential methods of total body irradiation.

Posted on October 31st 2010
Authors: Molloy JA Improvements in delivery techniques for total body irradiation (TBI) using Tomotherapy and intensity modulated radiation therapy have been proven feasible. Despite the promise of improved dose conformality, the application of these "sequential" techniques has been hampered by concerns over dose heterogeneity to circulating blood. The present study was conducted to provide quantitative evidence regarding the potential clinical impact of this heterogeneity. PMID: 21158268 [PubMed - in process] (Source: Medical Physics)


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Hospitalizations and Emergency Department Visits for TBI in Ontario.

Posted on October 31st 2010
Conclusions: The study provides estimates for TBI from the only Canadian province that has systematically captured ED visits in a national registry. It shows the importance of tracking ED visits, in addition to hospitalizations, to capture the burden of TBI on the health care system. Prevention strategies should include information on ED visits, particularly for those at younger ages. PMID: 21059539 [PubMed - in process] (Source: The Canadian Journal of Neurological Sciences)


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Role of the S100B serum biomarker in the treatment of children suffering from mild traumatic brain injury.

Posted on October 31st 2010
Conclusions The vulnerability of S100B serum levels to the influences of patient age, blood sampling time, and extracranial S100B release limits the biomarker's role in the initial evaluation of children with mild TBI. The application of S100B in pediatric mild TBI cases has an elusive role, although it could help in selected cases to avoid unnecessary head CT scans. PMID: 21039136 [PubMed - in process] (Source: Neurosurgical Focus)


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Role of the S100B serum biomarker in the treatment of children suffering from mild traumatic brain injury.

Posted on October 31st 2010
Conclusions The vulnerability of S100B serum levels to the influences of patient age, blood sampling time, and extracranial S100B release limits the biomarker's role in the initial evaluation of children with mild TBI. The application of S100B in pediatric mild TBI cases has an elusive role, although it could help in selected cases to avoid unnecessary head CT scans. PMID: 21039136 [PubMed - in process] (Source: Neurosurgical Focus)


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TBI and melphalan followed by allogeneic hematopoietic SCT in children with advanced hematological malignancies

Posted on October 31st 2010
Authors: J Inagaki, Y Nagatoshi, M Sakiyama, Y Nomura, H Teranishi, T Sasaki & J Okamura (Source: Bone Marrow Transplantation)

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